Treatment of Localized (Unicentric) Castleman Disease
Surgery is the recommended treatment for people with localized Castleman disease. Removing the abnormal lymph node(s) appears to cure the disease. Symptoms such as fever and fatigue that are caused by the Castleman disease go away. Relapses are rare. Although not used as often, radiation is also effective in treating localized disease. Either of these treatments is usually curative.
Some patients with localized Castleman disease develop secondary amyloidosis, a condition in which abnormal proteins build up in the kidneys, skin, and some other organs. This accumulation does not progress once the lymph node affected by Castleman disease is removed.