General Considerations in the Treatment of Castleman Disease
Once localized Castleman disease is removed, the outlook is very good. But sometimes the surgeon cannot safely remove all the disease. This doesn’t necessarily mean it will come back. Even partial removal may help and the disease may not grow back.
The outlook (prognosis) for multicentric disease is not as good. Although treatment helps, cures are rare and the disease often comes back. In one study, by the end of 2?years, 50% of people with multicentric Castleman disease had died. The outlook is better if the Castleman disease is not associated with HIV infection and AIDS. Another problem is that about 20% of people with the multicentric form of the disease develop lymphomas, which also affects treatment and outlook. Kaposi sarcoma is another cancer that is associated with HIV infection and AIDS. Some people with Castleman disease and AIDS also have Kaposi sarcoma, which complicates their medical situation.